The University of Gothenburg has approximately 50,000 students (25,000 full-time students) and 5,000 employees. With its eight faculties, the University of Gothenburg is also the most wide-ranging and versatile university in Sweden. The Sahlgrenska Academy is the faculty of health sciences at the University of Gothenburg. Education and research are conducted within the fields of pharmacy, medicine, odontology and health care sciences involving about 4,000 undergraduate and 1,200 postgraduate students. The lead scientist Michael Breimer, Prof. of Clinical Molecular Genetics and Consultant surgeon at the Department of surgery, is the leader of the Gothenburg group. He has 40 years of basic and clinical research experience within carbohydrate biochemistry, glycobiology and xeno/allo-transplantation and published more than 100 original scientific articles within these areas. He also has clinical competence in general surgery and transplantation. The experimental work will be conducted at the Departments of Medical Biochemistry (S Teneberg) and Clinical Chemistry/Transfusion medicine (M Breimer, J Holgersson). These laboratories are fully equipped for the isolation and structural characterisation of glycolipids, released saccharides from glycoproteins/mucins and characterisation of the humoral immune response towards carbohydrate antigens. The Sahlgrenska academy core facilities for proton NMR spectroscopy and mass spectrometry are accessible and used by the group members since many years
In the TRANSLINK project UGOT will screening of patient sera against libraries of glycolipids and recombinant mucins with known chemical structures. De novo identification of putative targets for anti-carbohydrate antibodies causing BHV complications. This involves isolating and structurally characterizing lipid- and proteincarried carbohydrate determinants acting as targets for anti-BHV antibodies. Cutting edge techniques such as mass spectrometry, liquid-chromatography and proton NMR spectroscopy will be used. Studies of cellular, in particular NK cells, interactions with BHV.
Methods and technologies are available in the labs of partner UGOT to solve these tasks.
Contributors to TRANSLINK:
- Prof. Jan Holgersson, MD PhD, Professor of Transplantation Immunology at the Sahlgrenska Academy,
- Prof. Susann Teneberg, MD, PhD, Professor of Medical Biochemistry at the Institute of Biomedicin.
- Dr. Jining Liu, MD, PhD, endocrinologist
- Dr. Angela Barone, PhD Molecular Geneticist at the Sahlgrenska Academy at University of Gothenburg and the Sahlgrenska University Hospital