University of California-Davis (UC-Davis) is a 501(c)(3) non-profit entity. It is a top public university and one of the world’s leading cross-disciplinary research and teaching institutions. It is one of the Ten University of California campuses. Department of Chemistry at UC-Davis has 40 research active faculty members working in interdisciplinary research, many are word leaders in their research fields. The UC Davis Facility for Advanced Instrumentation maintains state-of-the-art equipment for mass spectrometry and other analytical separations (HPLC and capillary electrophoresis). The UC Davis NMR Facility provides access to Avance 800 MHz, Avance 600 MHz, VNMRS 600 MHz, Avance 500 MHz, Avance 400 MHz, Biospec-7T 300 MHz, and Tecmag 26 MHz NMR instruments. The Department of Chemistry provides access to in-house NMR instruments (300, 400, and 600 MHz) as well as excellent small molecule X-ray crystallography equipment, Mattson Galaxy FT-IR, Silicon Graphics IRIS 40/50GT Graphic Image Processor System, Biacore Surface Plasmon Resoncenc (SPR) system, DEC VAX 11/750 Mini-Computer, Data General Eclipse MV/10000 Mini-Computer, Fluorescence Perkin Elmer MFP-44B, Cary 17 UV, HP 8450A UV, Spex Laser Raman, ESR Varian 4, ESR Brucker ER 200D, JASCO ORD/UV-5, JASCO DIP- 370 Polarimeter, Picker Nuclear X-Ray Diffractometer System, Syntex X-Ray Diffractometer System, Data General 8597-H Eclipse Computer System, Vaxstation 3200 Mini Computer, Tektronic 4106 Graphics Display Terminal.
Prof. Chen’s group at UC-Davis will develop and apply efficient chemoenzymatic methods for synthesizing glycans to be used to generate glycan microarrays as essential tools for the proposed project. In addition, Prof. Chen’s expertise on the scope of the glycans to be included in the array will also be critical for the project. Prof. Chen has the expertise in developing efficient chemoenzymatic methods for synthesizing complex glycans, glycopeptides, glycolipids, and other glycoconjugates as well as carbohydrate-based inhibitors. Her group is also experienced in carrying out functional studies of carbohydrate-containing compounds in her own laboratories and by collaboration with her collaborators. By collaborating with her colleague, structure biologist Prof. Andrew Fisher, they solve crystal structures of glycosyltransferases and other carbohydrate biosynthetic enzymes. Her group is also experienced in protein crystal structure-based site directed mutagenesis for generating glycosyltransferases with improved functions.
Contributors to TRANLINK:
- Prof. Xi Chen, PhD, Professor